Adequate hydration of patients receiving oral or intravenous LEVAQUIN® should be maintained to prevent the formation of highly concentrated urine. Crystalluria and cylindruria have been reported with quinolones see Adverse Reactions (6.1) and Patient Counseling Information (17.2). LEVAQUIN® is indicated for the treatment of uncomplicated urinary tract infections (mild to moderate) due to Escherichia coli, Klebsiella pneumoniae, or Staphylococcus saprophyticus. LEVAQUIN® is indicated for the treatment of uncomplicated skin and skin structure infections (mild to moderate) including abscesses, cellulitis, furuncles, impetigo, pyoderma, wound infections, due to methicillin-susceptible Staphylococcus aureus, or Streptococcus pyogenes. LEVAQUIN® is indicated for the treatment of acute bacterial exacerbation of chronic bronchitis due to methicillin-susceptible Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, or Moraxella catarrhalis. RxReasoner is an online resource that provides extensive knowledge about medicines and offers clinical decision support services.
You shouldn’t drive, use machinery, or do other tasks that require alertness or coordination until you know how it affects you. Filter out the noise and nurture your inbox with health and wellness advice that’s inclusive and rooted in medical expertise. When taking amoxicillin antibiotics, be aware they can bind with calcium and inhibit absorption. Quickly reporting these symptoms can prevent more serious health problems and ensure timely changes to your treatment plan.
Dosage of LEVAQUIN® Tablets in Adult Patients with Creatinine Clearance ≥ 50 mL/minute
LEVAQUIN Injection is indicated when intravenous administration offers a route of administration advantageous to the patient (e.g., patient cannot tolerate an oral dosage form). The dosage of LEVAQUIN® Tablets for inhalational anthrax (post-exposure) and plague in pediatric patients who weigh 30 kg or greater is described below in Table 2. LEVAQUIN® Tablets cannot be administered to patients who weigh less than 30 kg because of the limitations of the available strength. These agents should be taken at least two hours before or two hours after oral levofloxacin administration.
Related/similar drugs
- The medication can also treat urinary tract infections, including complicated kidney infections that haven’t responded to other antibiotics.
- Stop taking levofloxacin tablets and tell your healthcare provider right away if you have yellowing of your skin or white part of your eyes, or if you have dark urine.
- Dose adjustment should be exercised during Levofloxacin ingestion in presence of renal insufficiency & hepatic insufficiency.
- You should not take levofloxacin if you’re allergic to it or other fluoroquinolone antibiotics like ciprofloxacin or moxifloxacin.
The microbiologic eradication rate by patient infection at 5 to 18 days after completion of therapy was 75% in the levofloxacin group and 76.8% in the ciprofloxacin group (95% CI -12.58, 8.98 for levofloxacin minus ciprofloxacin). The overall eradication rates for pathogens of interest are presented in Table 19. Levofloxacin and other quinolones have been shown to cause arthropathy in immature animals of most species tested see Warnings and Precautions (5.10). In immature dogs (4 to 5 months old), oral doses of 10 mg/kg/day for 7 days and intravenous doses of 4 mg/kg/day for 14 days of levofloxacin resulted in arthropathic lesions. Three-month-old beagle dogs dosed orally with levofloxacin at 40 mg/kg/day exhibited clinically severe arthrotoxicity resulting in the termination of dosing at Day 8 of a 14 day dosing routine. Slight musculoskeletal clinical effects, in the absence of gross pathological or histopathological effects, resulted from the lowest dose level of 2.5 mg/kg/day (approximately 0.2 fold the pediatric dose based upon AUC comparisons).
tablet
This procedure uses paper disks impregnated with 5 mcg levofloxacin to test the susceptibility of microorganisms to levofloxacin. Pharmacokinetic studies in hepatically impaired patients have not been conducted. Due to the limited extent of levofloxacin metabolism, the pharmacokinetics of levofloxacin are not expected to be affected by hepatic impairment See Use in Specific Populations (8.7). Quinolones, including levofloxacin, cause arthropathy and osteochondrosis in juvenile animals of several species.
- Nerves are the fibers that carry sensations from your body to the brain.
- LEVAQUIN® is indicated for the treatment of acute pyelonephritis caused by Escherichia coli, including cases with concurrent bacteremia see Clinical Studies (14.7, 14.8).
- Patients should drink fluids liberally while taking levofloxacin to avoid formation of a highly concentrated urine and crystal formation in the urine.
Renal Impairment
Your skin may be very sensitive to light from the sun and devices that give off similar light, such as sunlamps and tanning beds, while you are taking certain drugs, including levofloxacin. Use sunscreen and wear a hat and clothes that cover your skin if you need to be in the sunlight. Exposing your skin to this kind of light, even for a short time, can cause your skin to be severely sunburned, blistered, or swollen.
Prolonged LEVAQUIN® therapy in adults should only be used when the benefit outweighs the risk. Some fluoroquinolones, including LEVAQUIN®, may produce false-positive urine screening results for opiates using commercially available immunoassay kits. Prescribing LEVAQUIN® in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria see Patient Counseling Information (17.1). LEVAQUIN® is indicated for the treatment of complicated urinary tract infections due to Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis see Clinical Studies (14.7). LEVAQUIN® is indicated for the treatment of complicated skin and skin structure infections due to methicillin-susceptible Staphylococcus aureus, Enterococcus faecalis, Streptococcus pyogenes, or Proteus mirabilis see Clinical Studies (14.5).
4 Drug Interaction with Chelation Agents: Antacids, Sucralfate, Metal Cations, Multivitamins
If you have kidney problems, your doctor will adjust your dosage and how often you take this drug. This list does not contain levofloxacin oral route proper use all drugs that may interact with levofloxacin. If they’re more severe or don’t go away, talk to your doctor or pharmacist. Get clear advice on liquid ivermectin dosage for humans, side effects, and safe use.
Do not take LEVAQUIN® if you have ever had a severe allergic reaction to an antibiotic known as a fluoroquinolone, or if you are allergic to any of the ingredients in LEVAQUIN®. See the list of the ingredients in LEVAQUIN® at end of this Medication Guide. LEVAQUIN® is a synthetic broad-spectrum antibacterial agent for oral and intravenous administration.
see Warnings and Precautions (5.9) and Animal Toxicology and/or Pharmacology (13.2). LEVAQUIN® is contraindicated in persons with known hypersensitivity to levofloxacin, or other quinolone antibacterials see Warnings and Precautions (5.2). LEVAQUIN® is indicated for the treatment of acute pyelonephritis caused by Escherichia coli, including cases with concurrent bacteremia see Clinical Studies (14.7, 14.8). LEVAQUIN® is indicated for the treatment of chronic bacterial prostatitis due to Escherichia coli, Enterococcus faecalis, or methicillin-susceptible Staphylococcus epidermidis see Clinical Studies (14.6).
IV Preparation
Table 8 lists adverse reactions that have been identified during post-approval use of LEVAQUIN®. Since no preservative or bacteriostatic agent is present in this product, aseptic technique must be used in preparation of the final intravenous solution. Since the vials are for single-use only, any unused portion remaining in the vial should be discarded. LEVAQUIN® is a fluoroquinolone antibacterial indicated in adults (≥18 years of age) with infections caused by designated, susceptible bacteria (1, 12.4). The dosage in pediatric patients ≥6 months of age is described below in Table 2.
Stopping early can allow bacteria to survive and potentially develop resistance to the medication. If you take too many levofloxacin tablets, call your healthcare provider or get medical help right away. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.Levofloxacin tablets and other medicines can affect each other causing side effects.
However, information pertaining to extended use at 500 mg daily up to 60 days is limited. Prolonged levofloxacin therapy in adults should only be used when the benefit outweighs the risk. In vitro and in vivo studies in animals indicate that levofloxacin is neither an enzyme inducer nor inhibitor in the human therapeutic plasma concentration range; therefore, no drug metabolizing enzyme-related interactions with other drugs or agents are anticipated. Prescribing levofloxacin in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria see Patient Counseling Information (17.1).